IV Sedation

Photo of dentist Gordon Laurie BDS
Written by the Dental Fear Central Web Team and reviewed by Gordon Laurie BDS, a specialist in Special Care Dentistry
Last updated on October 31, 2022

IV sedation is when a calming drug, usually midazolam, is given into your arm or hand during dental treatment (IV stands for intravenous). The drug relaxes you and makes you feel sleepy.

IV conscious sedation is the strongest form of sedation available in the UK and Ireland in general dental practice. Although you’re not fully put to sleep, you don’t tend to remember much (if anything) about the treatment. Any anxiety goes, and lots of people love how they are able to have treatment without even having to ‘experience’ it as such. 

Real Life Stories: IV Sedation Experiences

Read some of the stories that people have shared on our dental phobia support forum:

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What does IV sedation feel like?

During IV sedation, you will feel deeply relaxed and your anxiety will be greatly reduced. You will be less aware of what is happening, and you may feel sleepy. You will, however, be able to understand and respond to requests from your dentist, and you can let them know how you feel. Afterwards, you may not remember much about the procedure. Many people remember nothing at all.

First-hand accounts of IV sedation

Basically, it’s just a tiny pinch in the back of the hand and in goes the ‘stuff’. Nothing happens for several seconds and then you begin to feel light-headed (a little drunk) for a few moments, which is not unpleasant. Then instantly several hours have magically passed and everything has been done. It’s like the flick of a switch which turns your brain off for an hour or two. You feel fairly dopey and woozy afterwards where you may want to go and sleep it off.

I’ve had IV sedation for an extraction. You feel extremely relaxed, very fuzzy in a pleasant way. Nothing whatsoever bothers you about the situation. You’re able to respond to the dentist and do what they ask. The drugs make the time seem to pass in an instant, and often you don’t remember anything of what happened – I certainly don’t remember much at all. You’ll need someone to take you home as you’ll be a bit woozy; I slept all afternoon and woke up feeling fine.

Will I be asleep?


Some dental websites use terms like “sleep dentistry” or “twilight sleep” when talking about IV sedation. This is misleading because it suggests that IV sedation involves being asleep or unconscious. These terms are more descriptive of deep sedation.

Deep sedation isn’t common in the UK and would count as general anaesthesia (even though sedation occurs on a continuum).

You stay conscious and awake during conscious IV sedation. However, you may not remember much (or anything at all) about what went on. Here’s why:

  1. you will feel deeply relaxed and not bothered by what’s going on
  2. the drugs used for IV sedation will cause memory loss for when the drug first kicks in until it wears off. As a result, time will appear to pass very quickly and you won’t recall much of what happened. Some people remember nothing at all. So it may, indeed, feel as if you were asleep during the procedure.

Some common concerns about IV sedation

1. Can IV sedation make you feel light-headed or spaced out?

IV doesn’t make you light-headed. It’s best described as a sort of mellowed-out and relaxed feeling (as opposed to a drowsy or spacey feeling), but you may not actually remember what it felt like.

2. Can IV sedation make you feel nauseous or sick?

Quite the opposite! IV sedation suppresses nausea very effectively. This means it’s suitable for those who are concerned about getting sick.

3. I’m scared of feeling out of control

There is nothing to stop you from working out a “stop” signal in advance. Even after the IV line is in, you won’t be paralysed and you can still talk. You can also still withdraw your consent. There may be some points during a procedure where stopping wouldn’t be a great idea, but just knowing you can stop things helps most people.

4. What if I “fight” the sedation?

You may have come across stories on the Internet about people for whom IV sedation didn’t work. This is very rare.

For example, sometimes people who have been on benzodiazepines (the type of drug used for IV sedation) for long periods of time may have developed a tolerance to them.

Other times, the sedationist may have been a bit inexperienced and perhaps did not administer the drug correctly, or in sufficient quantities. It might be that the line wasn’t going into a vein properly and thus the person was getting the drugs IM (intramuscularly) instead of IV (intravenously), which has much poorer uptake and a much slower onset. 

But the vast majority of the time, and with a dentist you trust, IV sedation works really well!

I’ve never met anyone who could “fight off” IV with the power of their mind :-). – Gordon Laurie, BDS

5. I have a fear of numbness – what happens if I come around and panic because I feel numb?

The good news is that usually, by the time the IV has worn off, so has the numb feeling! You can find more information on this common fear here: Fear of Feeling Numb

How is IV sedation given?

The drug goes into a vein in the arm or back of the hand, using a cannula called Venflon. The Venflon has a very fine needle which is wrapped up with a tiny soft plastic tube. Once the Venflon has been inserted into the chosen site, the needle is then slid out, leaving only the thin flexible tube in place.

It takes about 3 to 5 minutes for the IV sedation to take effect for most people. The IV drugs are administered a little bit at a time, and your dental team will be by your side throughout.

If you’d like to know all the details, here is a description of how IV sedation is given.

Is it still necessary to have local anaesthetic (an injection in the gums)?

The drugs dentists usually use for IV sedation are not painkillers. While they relax you and make you forget what happens, you’ll still need numbing with local anaesthetic.

Will my dentist numb me before or after I’m sedated?

If you have a fear of dental injections, you won’t be numbed until the IV sedation has fully kicked in. By then, you’ll probably be so relaxed that you don’t care. Your dentist will then wait until you’re fully numb before starting on any procedure.

But how does the dentist know whether I’m numb?

You check the local anaesthetic has worked by asking the patient. Just because they’re sedated doesn’t mean they can’t answer you… in fact, they better be able to answer or they ain’t sedated, they’re anaesthetised! If they’re not numb enough they’ll soon tell you. But they won’t remember telling you of course because of the amnesia effect… – Gordon Laurie, BDS

What can I do if I’m terrified of the IV needle?

Make sure you discuss your fear with your dentist. They may have ideas for helping you with your fear.


If you worry about pain from the IV insertion, here’s a tip – get Ametop numbing gel to make the site where the needle goes profoundly numb:

A photo of Ametop Topical Gel, which makes the site where the IV sedation needle goes in profoundly numb

AMETOP numbing cream. I have a mortal fear of needles, and I find injections unbearable. Every injection I’ve had in my life has been intolerable. However, my dentist managed to get the IV in without me even noticing. I actually just turned around and it was in. The stuff is that good. I did not even feel any pressure. You can get a tube of it from your pharmacist for a few pounds, and it needs to stay in the fridge. If you need proof, buy two tubes, and use one a couple of days before your operation, just to reassure yourself how deeply numb it makes you. – from our message board

Ask your dentist or oral surgeon where the IV will be going in (before the actual IV appointment), and try it out! You should apply Ametop 30-45 minutes in advance. The numbing effect remains for 4 to 6 hours. You will probably have to order it in, as it’s not usually in stock in pharmacies. So plan ahead.

Ametop isn’t available in the U.S., but there is an alternative which also gets rave reviews from needle phobics: the Synera patch. This is just as effective. 1 In some European countries, but not in the UK, you can buy the Synera patch under the name Rapydan.

If you can’t get hold of either of these, use EMLA cream instead. For best effect, apply EMLA cream an hour or two beforehand.

Combining IV sedation with other forms of sedation or hypnosis

Many people find that having nitrous oxide or taking anti-anxiety medication beforehand helps them feel so relaxed that they’re able to go ahead with the IV. Alternatively, hypnosis can work really well.

Alternatives to IV sedation

IV sedation may not be suitable if you have an extreme needle phobia. In that case, you can take midazolam in a drink or even as a nasal spray. But usually, IV sedation is preferable because you can fine-tune the dose. This makes it more predictable and controlled.

Can I take valium tablets or similar beforehand?

Yes. You must let your dentist know about it though (unless your dentist has prescribed them and knows already). It’s best to do this in advance because you’re likely to forget to mention it on the day of the appointment.

What about eating and drinking before IV sedation?

Many dentists in the UK are happy for you to eat a light meal before IV sedation

Nowadays, many dentists are happy for you to eat and drink on the day of your appointment, as long as you avoid alcoholic drinks and large meals. Some dentists like to have people eat a light meal (some soup or a piece of toast with spread) an hour or two before they come in.

If there is any chance of oversedation (and the loss of protective airway reflexes), you may have to fast. This is more likely if the dentist or anaesthetist uses an advanced technique (see below), rather than standard single-drug midazolam IV sedation. There may also be risk factors that are particular to you, so follow your dentist’s advice on fasting.

What drugs are used? Are there different types of IV sedation?

In the UK, the standard technique is a titrated dose of midazolam. ‘Titrated’ means that the drug is given bit by bit until you get the desired effect.

1) The Standard Technique: Midazolam

Midazolam is a short-acting benzodiazepine, an anti-anxiety sedative. IV-administered midazolam has 3 main effects:

  • it reduces anxiety and relaxes you,
  • it makes you sleepy,
  • and it makes you forget what happened during some or all of the appointment.

Midazolam is given at a rate of 1 mg per minute. The dental team will monitor how you respond to the drug. Interestingly, the amount you need doesn’t just depend on your size or weight – everyone reacts differently. Once you’ve reached the desired level of sedation, the drug is stopped.

The Venflon is left in place during the procedure. That way, the sedation can be topped up. It also means that if needed, a reversal agent for benzodiazepine (called Flumazenil) can be put in.

2) Remimazolam

Remimazolam (tradename: byfavo) is a brand new benzodiazepine sedation drug – exciting, eh? Unlike midazolam, it wears off very quickly, so you need to top it up every 12 minutes or so.

This can actually be a huge advantage, especially for shorter appointments. “Why?”, you might ask. Well, for one thing, you’ll be much more aware when you’re discharged. This is especially important if the “responsible adult” who acts as your escort turns out to be not quite as responsible or reliable as you’d hoped! And, of course, you can enjoy the rest of the day more fully (and celebrate your success) if you feel more alert.

Secondly, remimazolam is super safe, seeing how any overdose will quickly wear off. You can keep topping it up without it accumulating in the body.

Thirdly, remimazolam is broken down by an enzyme in the tissues rather than in the liver. This makes it really useful and much safer for elderly people whose livers cannot break down midazolam quickly.

Remimazolam (trademark: byfavo) is a new drug for IV dental sedation

So, what’s not to like?

There are actually a couple of disadvantages – it costs a lot more than midazolam (though that may change over time), and constant topping up can be distracting if the dentist is also the one administering the sedation.

But overall, remimazolam is a great new development, especially for shorter appointments and older adults.

Remimazolam has been approved for dental sedation in the UK but it’s still unclear whether dentists can just start using it or if they need to do a number of cases under supervision, so watch this space!

3) Advanced Techniques

In the UK, it is really quite rare to use anything other than straightforward midazolam. Advanced techniques are only used if “the clinical needs of the person are not suited to sedation using a standard technique” 2. Usually, advanced techniques are used in hospital environments only, and the sedationist has to be “suitably experienced”. Drug combinations have less predictable effects than single drugs and they don’t have the same margin of safety, so their use is uncommon.


One drug which is occasionally added on to midazolam is fentanyl (an opioid).

On the face of it, adding opioids might seem appealing, because of the pain-killing factor. But in the normal way, this would only come into play for post-treatment pain, because local anaesthetic will take care of any pain during treatment. Actually, where post-op pain is likely, you can simply give a long-acting local anaesthetic and take over-the-counter painkillers before the local anaesthetic wears off.

However, the addition of an opioid can be useful if the sedation for some reason isn’t effective enough. This is more likely if you’ve been using benzodiazepines for many years and have developed a high tolerance to them. In this case, adding an opioid may achieve the desired level of sedation.


As an alternative or in addition to midazolam, the sedationist may use propofol. Propofol is classed as a GA drug, because it’s very easy to tip over into GA (general anaesthesia) with it. In the UK, it can only be used in a hospital setting (although a few private dental clinics meet the standard of a hospital setting, and offer it as well). One advantage of propofol is the very rapid recovery time, less than 5 minutes.

Again, propofol can be useful for the small percentage of people for whom the standard technique doesn’t work.

How common is the use of multiple drugs?

In the U.S., the use of polypharmacy (multiple drugs) is much more common, possibly because IV sedation is taught at a high level. Also, there appears to be more of a liking for long IV sessions which require polydrug use. Long IV sessions may be driven by consumer demand, or maybe it’s a training issue. Many IV specialists in the United States don’t like using opioids for sedation, but there is a habit of using them ingrained in many practitioners. However, things appear to be changing as new dentists are coming through.

The general consensus among the experts in the field of dental sedation today is: the fewer medications are used, the safer and more predictable the treatment tends to be. Usually, this means one medication only. Midazolam tends to be the drug of choice. Advanced techniques can, however, be very useful where an experienced practitioner has tried midazolam and it didn’t have the desired effect.

Is it safe?

IV sedation is extremely safe when carried out under the supervision of a specially-trained dentist. In a recent review of studies looking at death rates related to dental anaesthesia, the studies looking at IV sedation reported a death rate of precisely zero 3.

If you become too drowsy, it is easy to give a drug (Flumazenil) that reverses the effects.

Are there any contraindications?

A contraindication is where a drug or procedure should not be used because it could be harmful. The main contraindications to IV sedation in general practice (out of hospital) are:

  • being overweight with a high BMI (a common cut-off is a BMI higher than 35)
  • high blood pressure with a diastolic pressure over 100.

Others include

  • pregnancy and breastfeeding
  • known allergy to benzodiazepines
  • being drunk
  • some instances of glaucoma.

Cautions (relative contraindications) include psychosis, impaired lung or kidney or liver function, advanced age, and sleep apnoea. Many people who have sleep apnoea don’t have an official diagnosis – if you’re overweight and you snore, do mention this.

Heart disease is generally not a contraindication to IV sedation.

If you’ve been taking benzodiazepines for many years, your tolerance may be high – so let your dentist know that you’ve been taking them!

Do I need to go to a hospital for treatment?

The Dental Sedation Teachers Group uses the following classification for making the decision if and where conscious sedation should be provided:

  • I – Normal, healthy patient
  • II – A Patient with mild systemic disease, e.g. well-controlled diabetes or epilepsy, mild asthma
  • III – A patient with severe systemic disease limiting activity but not incapacitating, e. g. epilepsy with frequent fitting, uncontrolled high blood pressure, recent heart attack
  • IV – A patient (usually hospitalised or bedridden) with incapacitating disease that is a constant threat to life
  • V – A patient who is expected to die within 24 hours with or without treatment

(source: American Society of Anaesthesiology Classification of Physical Status (ASA))

If you’re in category I or II, you can normally be treated in general practice.
Those in category III should have treatment in a hospital-based clinic or a sedation clinic where medical support is available.

What are the advantages of IV sedation?

Advantages of IV sedation
  • IV sedation is the method of choice if you don’t want to be aware of the procedure.
  • The maximum level of sedation with IV is deeper than with oral or inhalation sedation.
  • It’s very effective and reliable. The level of sedation can be tailored to your needs. This is a huge advantage compared to oral sedation.
  • Benzodiazepines produce memory loss for the procedure.
  • You can do a lot of dental work in one fell swoop.
  • If you have a very severe gag reflex, IV sedation can pretty much eliminate that.
  • Unlike General Anaesthesia or Deep Sedation, conscious IV sedation doesn’t really introduce any compromises in terms of carrying out the actual procedures. That’s because you’re conscious and you can cooperate with instructions, and there is no airway tube getting in the way.

Are there any disadvantages?

  • While people like IV precisely sedation because of the amnesia effect, there can be a downside to this. If you can’t remember that the procedure wasn’t uncomfortable or scary, you may be less likely to unlearn your fears. And if you are still anxious, you may slip into an avoidance pattern more easily. Other people argue that this is not a concern if IV sedation was readily available for everyone who needs it.
  • Some dentists may resort to IV sedation too quickly. Sedation is not a replacement for TLC, painless dentistry and non-drug ways of helping. You should want IV sedation, rather than feel forced into it because your dentist isn’t keen on exploring other ways of helping you.
  • IV drugs take a while to wear off. You must bring a responsible adult with you who will take you home after your appointment and look after you for the rest of the day.
  • Occasionally, there can be bruising to your hand or arm at the injection site. But this should only last a few days.
  • IV sedation is more expensive than other types of sedation.

Is IV sedation available on the NHS?

The NHS website’s advice, on their “Fear of the Dentist” page, was to ask your dentist to refer you to an NHS sedation clinic. While the page has been removed, presumably you can still ask your dentist for such a referral (or for a referral to the community dental service). In Scotland, you can ask your GP or dentist for a referral to the Community Dental Service or Primary Care Salaried Dental Services.

After IV Sedation

  1. Have your escort take you home by car or taxi and rest (not public transport). No shopping trips, please!
  2. Have an adult stay with you for the rest of the day.
  3. Don’t drive or ride a bike for until the following day.
  4. Leave the cooking to someone else, and don’t operate any machinery. This includes domestic appliances and kettles!
  5. Avoid climbing ladders or similar.
  6. Don’t sign any contracts or make important decisions.
  7. Get another adult to look after children for the rest of the day.
  8. Stay away from the internet (especially shopping websites and social media sites…).
  9. Don’t drink alcohol for the rest of the day.
  10. Continue your usual medication as normal (unless your dentist says otherwise), and take any additional medications as directed by your dentist.
  11. If you have any unusual problems, call your dentist.

Further Reading

Standards for Conscious Sedation in the Provision of Dental Care (2015). The dental faculties of the royal colleges of surgeons and the Royal College of Anaesthetists.

Conscious Sedation in Dentistry – Dental Clinical Guidance Third Edition (2017). Scottish Dental Clinical Effectiveness Programme – NHS Education for Scotland.

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Sources of Information

  1. Ravishankar, N.; Howell, S. J.; Elliot, S.; Beardow, Z.; Mallick, A. (2012). A comparison of Rapydan® patch and Ametop® gel for venous cannulation. Anaesthesia, Vol. 67, Issue 4, pp 367-370. https://doi.org/10.1111/j.1365-2044.2011.07000.x[]
  2. Conscious Sedation in Dentistry, Third Edition, June 2017, Scottish Dental Clinical Effectiveness Programme[]
  3. Hamed Mortazavi, Maryam Baharvand and Yaser Safi. Death Rate of Dental Anaesthesia (2017). J Clin Diagn Res. Jun; 11(6): ZE07–ZE09.[]